Your worst case scenario is data landing 1/2 way between clicks. At 1000 yards, 1 click on a 1/4 MOA scope = 2.62", so worst case is 1.31" @ 1000 yards. It takes some darn good drop data and shooting to be able to blame a miss on that.
Its the same as a shot being 1/8th of an inch from where it was supposed to be at 100 yards and thats only if the data falls right between clicks. Usually it will be closer to one click or another so its really tough to shoot at a level where its a factor.