Initially, I wasn't going to engage this discussion because for the pure, simple fact that the only thing i've hunted are whitetails. While occasionally tenacious, they lack teeth, claws and at least 300lbs to be anywhere near what revvystroke asked about.
Also, as is always a primary consideration, not much replaces good shot placement - at least until we get into 20mm and larger
Further, excellent bullet choice must also be a primary consideration as well as enough HP to get the job done.
Given the question about 7mm being enough, it makes perfectly good sense to me that anything thats big and powerful w/claws and teeth is on the list for a one-rifle battery, a minimum is going to be .338 cal.
I don't care that a 7mm *can* do the job on these big critters (and i really, really like the 7mm caliber, but for light-ish skinned/non-'dense' animals). I want something that will flat-out knock that bear on his ear - no questions or reservations. If it will knock the stuffing out of a big bear, then it will certainly have enough juice for a moose.
To me, as i've beening planning/re-planning my own battery, a 7mm RM is definitely a primary in my line-up (despite some other excellent high-power 7mm's). However, if/ when i ever get a chance for larger game (thinking specifically big bears), then a big .338 must be added. I'd probably go with a 338RUM since factory ammo should be reasonable to locate if my handloads got lost.
Also, range does come into account to the extent that rifle form inhibits the type of hunting. Its hard handling a (scoped) long-range rifle in thick, dark foliage. If that terrain were my hunting area then a shorter rifle would be on the list .45-70 Marlin lever-gun with heavy loading or a .375 Ruger Alaskan. Something that, in close-quarters, will *really* put the advantange in my court.