^^^^ Shame on me for considering myself a Savage Fan, I didn't know that was available, i'd like to try that out (I have the Ruger Hawkeye in 375R). The 375 Ruger would be a good choice for sure. But if we're talking about a 1500 lb buff you really won't need it (per say). I live very close to a few buffalo/bison ranches (I think RBL closed), there were a lot of 2k lb'ers taken with the ole' 45-70 & 45-90. There's a lot to be said about a big
slow bullet..... there are also some taken with the 300wm, although the video I viewed was less than impressive as the big bull literally shrugged off several rounds at meager distance... you could actually see the hide twitch as if being bitten by a bug... didn't even quit eating until blood from the lungs was coming out. I do have a personal acquaintance who used a 325WSM to good
results on the "once in a lifetime, WY lisenced hunt".
My vote is for DIAMETER over velocity, 338 or bigger.... I just happen to have a Ruger #1 in 458 Lott sitting here with buff written all over it
Not to mention, you now have an excuse to build/buy another rifle! How can you loose!