I run a suppressor on my 243,260 and 308.
The good: much more pleasent to shoot in general. once you shoot with one you feel stupid shooting without it. Its like running your car without a muffler.
Animals cant tell where the shot came from. they often run towards you.
The bad: The weight and added length. My 243 and 260 have 26" barrels add 9" of suppressor makes them pretty awkward. my 308 has a 20" barrel wish I had gone 18". Get a titamium one if you can swing it. When I know I am going to be hiking a long ways I leave it off due to the weight.