I have been using the .308 178gr Amax for the last 2 years. I used it last year on antelope and mule deer. I shoot a .308 Winchester and have found that at the lower velocities (2700 fps) they are excellent.
You can see pics of the deer and entrance/exit wounds here (just scroll down to the post by user jamesmc2)
amax for big game
They provide nice expansion and a devestating wound channel through the vital organs. This year I went on a high desert elk hunt. Lots of open terrain with 300-400yd shots being common. I worked up a "stalking" load with the 180gr Hornady Interlock for shots less than 200yds and stuck with the 178gr Amax for my long range load.
While working into position on a bull about a 1/2 mile away I bumped a nice six point from his bed. He finally stopped at 320 yards. Both hits were quatering away. First entered the lower chest just in front of the heart and exited the neck on the opposite side. This broke ribs going in and out and left a 1.5 inch exit. This round alone would have been fatal as it destroyed several major blood vessels. He was stopped but still standing so I shot again. This second hit was in the high shoulder. It went through the upper scapula (which is only 1/4" thick) and penetrated the both upper lungs. The bullet was found under the hide on the off hand shoulder. Besides the scapula and ribs it had not hit any major bone. I would guess that weight retention was about 50%. In my opinion the bullet did a nice job. For those shooting faster velocities like a 300 WM or RUM I would say go with the 208gr Amax or another heavier built bullet. After three kills I think that for the .308 Win the 165gr or 178gr Amax is a nice hunting bullet. I use it because it is the most accurate bullet out of my gun.
Here is the pic of the elk killed by the 178gr Amax