60 grn bullets should shoot very well in a 12 twist. There's tons of options, from 55-60+ grns. H-380 is well known in 22-250, and Varget is great too.
If you want to load alot of ammo with minumal fuss, H-380 meters like hot butter. No reason to weigh charges once the meter is set up. Varget is a little slower because it's extruded. I weigh/trickle each charge when using Varget, but not necessary with H-380.
38-39 grns H380, 35-37 grns Varget.........work up carefully.