I show a MV of about 2885 FPS needed with the 750 A-Max at a BC of 1.05 to be zeroed at 1000yds with 21.5 moa dialed in.
Drop the MV to 2680 and you need 26.0 moa now and that's still at 90 deg. F too.
I would say in a case that large, you could expect velocity variations of a couple hundred FPS with different lots of brass pretty easily.
Combine that with a slight loss of velocity from the cartridge cooling off in the evening also.
A check of water capacity in each case lot of fired cases could verify it real quickly.
What angle uphill are you shooting?
An Oehler 35 would be earning it's keep in this situation for less than the price of two cans of ball ammo.
What type 50 do you have, and what length barrel? My brother has the LAR Grizzly with a 36" with the new style muzzle brake
and a Nightforce 5.5-22. Bitchin to shoot!!