Accuracy loads out of my 300 winchesters at sea level 100 yard zero.
180 Cutting Edge C21 at 1000 yards. drop 218", windage 57", 1791 fps, 1282 ft pounds.
210 Berger same parameters. Drop 273", windage 62", 1619 fps, 1222 ft. pounds.
The primary difference would be the energy with the CE 180 bullet would be very close since it retains around 95% of it's weight as a premium hunting bullet. The lead core bullet, of whichever manufacturer, depending on what velocity you hit the animal could lose quite a bit of weight therefore making energy figures with it useless.
This is a hunting forum and not a target forum so one thing hunters with limited experience need to look at is not using a bullet that exceeds the capability of your cartridge where range is concerned. Shooting targets at extreme long range well beyond 1000 yards a shooter would benefit by shooting a much heavier and greater BC bullet since killing performance is not a concern. A heavy for caliber bullet such as the Hornady Amax, Sierra matchking or Berger VLD for instance. But with hunting you must look at other parameters such as what is the top range my cartridge would be acceptable on big game performance. Then look at the best bullet for big game performance within that range. Also a bullet that performs well on game at 50 yards at high velocity and then at 1000 yards at slow velocity. 1000 yards is about where a guy should limit the 300 winchester and maybe closer on elk size game. At that point he should look at a cartridge with more performance.
Killing animals at long range is far more than just picking a bullet that looks good on a ballistics program.
I just wanted to come in here and add another important factor. I use my 300 winchester as a light backpack style rifle good to somewhere between 800-1000 yards. With the 180 grain bullet it is a pleasure to shoot and I can easily hold steady on long range targets with it. With heavy bullets it will knock the living crap out of me. I do not want a muzzle brake
on this type of rifle. If I use a muzzle brake or heavier rifle it is in a cartridge with far greater capability for long range hunting than a 300 winchester. The set up I use with the 300 winchester is excellent for a light rifle to 800-1000 yards. Scoped out it weighs 7 1/4 pounds. If I went with the heavier bullet that knocked the crap out of me then I am defeating the purpose to begin with and am going larger cartridge. If I shoot a heavy rifle I may as well shoot it in something with 1500+ yard capability. No difference in weight or hiking with it. My equipment is highly refined for a particular purpose when I pick that particular rifle up to go hunting.