Depends on many things including what your definition of LR shooting is.
Quick answer- For most big game cartridges it won't make much difference out to 5-600 yards. Beyond that, you better start to look more closely at what the BC will do.
I am judging by your post count and the question that you may not have much experience with LR shooting and ballistics in general. I would highly encourage you to get real familiar with the LR calculator on this site.
Long Range Hunting Ballistics Calculator
It is a great tool to learn on, easy to use and you can compare various bullets or cartridges side by side to see the differences. A very useful learning tool.