I shoot a lot of .260 Rem and .260 Ackley Improved and have been able to push Berger 140 grain Target VLD's at +3000 fps using the Ackley, a case stuffed full of powder and a very long barrel. That being said, I can't get those same results with a traditional hunting bullet even if I reload to the point of blowing primers.
For a hunting rifle I had a custom reamer made by David Mason that necked down Nosler 280 Ackley Improved brass to 6.5mm and stuffed the longest bullet I could find in it. I don't have the rifle built yet but with the heavy 160 grain 6.5mm sledgehammers, I'm looking to get 3000 fps or more out of a shorter 24-26 inch barrel.
I still love the smaller 6.5mm for everyday range shooting and "tactical competitions". Build up a 6.5x47 Lapua, 6.5 Creedmoore or .260 Remington and you'll have a very accurate, fun and easy on the recoil rifle.
But for elk, or black bear or a big ole pissed off cat, I'll take a long action cartridge and as much powder as I can pack into it.
Oh yeah, and using a necked down .280 Ackley reamer allows me to use .25-06, .270 and .30-06 brass as well as the .280 brass.