It all depends on if it will stabilize it or not. If it doesn't, it will work with lighter bullets. If it doesn't like the 100 grain bullets you could always say, ah well, it should have. Weatherby has a disclaimer on the older 1-12 twist barrels saying they may not stabilise the heavier bullets. With the 1-12 barrel .257Wby the hot setup was the 87 grain bullet.
Only accurate rifles are interesting.
Gordy and Brady.