Grandpa had one of the first .257 Weatherby rifles, a customized Mauser 98 from Weatherby's old southern California shop. That rifle dropped everything from ground squirrels through deer with aplomb. Quite a cartridge. Dad still has the old Mauser in the gunsafe, but man does it need a new barrel!
At closer (normal) hunting ranges - the .257's velocity can ruin a fair amount of meat, if that's a consideration for you.