Re: .25-06 VS .243
Another possibility not yet mentioned is the .257 AI. It gets close to the ballistics of the 25-06 while using considerably less powder, has the same bullet selection, the same hunting versatility, and you have a caliber a little different than the rest of the crowd if you like that. It will still shoot factory .257 Roberts ammo, and once shot, you have fire-formed cases to be loaded to the full power capability of the Ackley Improved version. Just a thought. I have one in 700 Rem that I wouldn't part with for a 25-06, .243 or any similar cartridge. It started off life as .257 Roberts and all I had to do was have it re-barreled to the Ackley Improved. You could just have it re-chambered for less money too.
Make the first shot count because more often than not the second one won't!