I've had a Sendero SF in .25-06 for about 10 years now. I shot it a little right after I got it and shot various 100 gn bullets (Ballistic Tip and TSX) in it at deer out to 200-250yds. Nothing really LR.
My youngest son took a liking to it over his .260 Mtn Rifle, so we swapped. We didn't get to hunt much together after that due to the "Big D", but I know he didn't shoot it more than 20 times after all this.
Then we swapped rifles again. I got the .25-06 back and he got my 700P in 7mmRemMag. I have taken several deer with it since this but stepped up, first, to the 115gn Ballistic TIp and now 115gn Berger. My rifle shoots all these great and I have not had any deer leave the "scene of the crime". Great deer killers all of 'em.
I believe that the 115gn Berger VLD Hunting offers the most as a package, compared with the others listed above. This is taking into consideration trajectory, expansion and pure killing/stopping power.
The farthest I have taken a deer with the Bergers is 315yds, this past year. I intentionally set up on fields that provide shots out to 700-800yds, but those "suicidal goats" walk out at 300yds. What's a guy supposed to do, shew 'em away?
Recently, within the past 6 months, I have started taking the 115gn Berger to 700yds +. Along with the .25-06 I shoot a .243, 6.5-284 and .300WinMag. The .25 does pretty good and does better than my .243 at the longer distances but I'm only shooting 90gn bullets in the little .243 at this time. It doesn't do quiet as good as the 6.5-284 and doesn't even compare with the .300WM.
All that to say, deer at 500 - 600 yds, heck yeah. A better selection of bullets could only make a great cartridge even better. Sorry this was so long but I just like rifles! JohnnyK.