[QUOTE=jkupper;859769]I have to agree with this. I have a 220, and my old man has a 22-250. I have shot antelope with my swift, and it did a fine job at 400 yards with 52 gr. Nosler CC's. I would shoot heavier bullets, but the twist rate on my factory barrel prohibits it, and I feel that 400 yards is the max distance with this combination on antelope, just a personal choice on that.
I have taken coyotes out to 600 yards with my 220 and the same load. I'm still waiting for a longer shot opportunity on a song dog with this gun.
Both are great calibers, but I am one of the people who are trying to keep the 220 Swift alive. I truly feel it is the better of the two cartridges, so long as you reload. If you are shooting factory ammunition then the 22-250 is probably the better choice simply because of the selection of factory ammo available.
When I burn the factory barrel out on my swift I plan to get a faster twist barrel so I can shoot the heavier bullets. Then I will be able to spread the wings on my Swift a bit
Both calibers are more than capable at 400 of dropping a goat. Seen it done ive done it not at 400 yards though. Ive killed mule deer and blacktails with both calibers. Its all about placement.