Rangerman, I have never shot a Bison, so I have no personal experience there. I have shot lots of elk and we took several with the 215 this past season. The largest being my bull shown below. I put the 215 Bereger behind the front shoulder in the crease and he took a few steps and was done. We also shot some other bulls and several cows with the 215 Berger and they all were one shot kills. If it were me and I felt that was the rifle and bullet I wanted to use I would try it. But again, I have never taken a Bison. In this thread I show pics of entrances and exits and internal damage from 19 big game kills with the 215 Berger. Maybe you have seen this? If not it may supply the info you are looking for to make your decision.
Good luck and have a great hunt.