The 40 S+W. Is really quite a round. I know of black bears that have been cleanly killed with a few well placed shots from them. Bears in the 6 1/2' square size. I heard of a guy that killed a moose with a 40. Clean kill.
Around here we have wolves, but they keep themselves real scarce. Total target of opportunity
. The bears here where we live tend to be small and mostly timid. Both grizzly and black bear. But cow moose are the biggest thing I worry about when my wife goes for a walk.
She currently packs a single stack 9 . LC9
I plan to upgrade here to an XD9 3" . Then an XD40. .
The brass on the ground is a problem but its better than here getting mauled.
And in Alaska women have been killed by wolves.