In my waking dreams, it is of course essential for long range hunting to have a new, just released scope and laser rangefinder to team up with a rifle and cartridge/bullet combo to do the job at ranges close, far and anywhere in between.
My test bed rifle is a Kimber Select Grade 8400 in .338 Winchester Magnum with the new Leupold VX-6 2x12 42mm with Boone and Crockett reticle. The cartridge is a hand loaded Nosler Custom Case and a 185 grain Nosler AccuBond using Reloader 15 powder. Clocking in at 3150 fps, the 185 grain pill is a veritable freight train of energy for any species in North America and most of Africa.
I have killed African game such as kudu, impala, springbok, and blesbok with a Ruger .338 with Nosler Partitions, some out to near 300 yards, but no farther. The Nosler folks suggest that the bullet will not mushroom effectively below 1800 fps. So my range is limited to shots where the energy drops to that level. I also factor in my shooting skills, knowledge of the range, angle of the shot, altitude, temperature and most importantly the wind. The wind in long range hunting beyond 300 yards is an often troublesome variable that can kill the best of long range shots.